TMKingdom
Transmembrane Kinase Kingdom

Developed by Plant Phytophthora Interaction Laboratory

TMKingdom is a massive transmembrane kinase (TMK) resource containing ~1.4M TMKs. The TMKs can be queried or analyzed at individual level (TMK), at species level (TMKome) or across species level (Cluster). In addition to annotation information including signal peptide, transmembrane and functional domains, TMKingdom also integrates other related informations such as 3D-structure, corresponding gene expression levels, ortholog, interaction and references and so on. It has five important highlights:

(I) Massive data resource It exhaustively collects 1,415,870 TMKs from 33,047 species covering the life kingdom of Metazoa, Viridiplantae, Fungi, Protists and Prokaryotes.

(II) Complete function annotation It greatly refines and improves function domain annotation with the combined method of deep learning, pfam motif search and 3D-structure similarity.

(III) Global structure clustering It open a new perspective for TMK function and evolution analyses through the whole life kingdom-wide TMK clustering based on 3D-structure similarity.

(IV) Diverse query functions It implements multiple querying interfaces, such as by IDs, species, sequence and 3D-structure similarity, to meet diverse retrieval demands.

(V) Powerful online analysis It supports various forms of online analysis, to help researchers understand the TMK characteristics of concerned species at omics level.

Curated TMKs 1,415,870		Covered species 33,047		Divided clusters 63,738
Comparison analysis Compare species groups to obtain TMK characteristics at omics levels		Protein-interaction Upload a PDB to screen for the TMK that is most likely to interact with it		Annotation server Annotate TMKs in transcriptome or proteome file uploaded by users

Contact: Jinding Liu, biotec(At)njau.edu.cn
©Bioinformatics Center and Plant Phytophthora Interaction Laboratory, Nanjing Agricultural University