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Description:
CRKs generally contain two cysteine-rich repeat domains that are highly similar to fungal lectins (Vaattovaara et al., 2019). However, the conserved C-X8-C-X2-C motif is distinct from that in G-type lectins. This domain is also known as DUF26 or stress-antifungal domain, plays because it has a role in salt stress response and has antifungal activity. To date, CRKs are associated with plant defense and oxidative stress responses, programmed cell death, and development (Dievart et al., 2020). The hidden Markov model (HMM) PF01657 was used for the CRK classification.

References:
1. Dievart A, Gottin C, Perin C, Ranwez V, Chantret N. 2020. Origin and diversity of plant receptor-like kinases. Annu Rev Plant Biol. 71:131-156. doi: 10.1146/annurev-arplant-073019-025927. PMID: 32186895.
2. Vaattovaara A, Brandt B, Rajaraman S, Safronov O, Veidenberg A, Luklova M, Kangasj?rvi J, L?ytynoja A, Hothorn M, Saloj?rvi J, Wrzaczek M. 2019. Mechanistic insights into the evolution of DUF26-containing proteins in land plants. Commun Biol. 2:56. doi: 10.1038/s42003-019-0306-9. PMID: 30775457.